This list contains the Partitioned Survival Model (PSM) parameters including various cost, probability, and utility values used in the model.
Format
A list with the following components:
- age
Starting age of simulated cohort, 4.
- body_weight
Body weight in kilograms, 15.
- smr_EFS
Standardized Mortality Ratio (SMR) for the Event Free Survival compared to the general population all-cause mortality, 5.6.
- smr_PPS
Standardized Mortality Ratio (SMR) for the Post Progression Survival compared to the general population all-cause mortality, 10.64.
- cure_threshold
The time in years at which those in the EFS are considered cured, 10. Beyond this time, the mortality hazard rates for the EFS and PPS is set by the `smr_EFS` and `smr_PPS` parameters, respectively.
- GD2_unit_mg
Unit dose of Dinutuximab β (GD2) in milligrams, 20.
- GD2_dose_days
Number of days on Dinutuximab β per cycle, 5.
- GD2_unit_price
Unit price of Dinutuximab β, 8790.26.
- TT_unit_mg
Unit dose of Isotretinoin (TT) in milligrams, 20.
- TT_dose_days
Number of days for Isotretinoin dosing, 14.
- TT_unit_price
Unit price of Isotretinoin, 0.24.
- GD2_aEvents_names
Names of adverse events for GD2:
- anemia
anemia
- leukopenia
leukopenia
- neutropenia
neutropenia
- thrombocytopenia
thrombocytopenia
- fever
Fever
- urticaria
urticaria
- immunotherapy_related_pain
immunotherapy related pain
- diarrhea
Diarrhea
- hypotension
hypotention
- vomiting
Vomiting
- infection
Infection
- hypersensitivity_reaction
Hypersensitivity reaction
- capillary_leak
Capillary leak
- prob_anemia
Probability of anemia, 0.42
- prob_leukopenia
Probability of leukopenia, 0.45
- prob_neutropenia
Probability of neutropenia, 0.33
- prob_thrombocytopenia
Probability of thrombocytopenia, 0.35
- prob_fever
Probability of Fever, 0.14
- prob_urticaria
Probability of urticaria, 0.05
- prob_immunotherapy_related_pain
Probability of immunotherapy related pain, 0.16
- prob_diarrhea
Probability of Diarrhea, 0.07
- prob_hypotension
Probability of hypotention, 0.08
- prob_vomiting
Probability of Vomiting, 0.06
- prob_infection
Probability of Infection, 0.25
- prob_hypersensitivity_reaction
Probability of Hypersensitivity reaction, 0.08
- prob_capillary_leak
Probability of Capillary leak, 0.1
- cost_anemia
Cost of anemia, 0.
- cost_leukopenia
Cost of leukopenia, 0
- cost_neutropenia
Cost of neutropenia, 0
- cost_thrombocytopenia
Cost of thrombocytopenia, 0
- cost_fever
Cost of Fever, 1.98
- cost_urticaria
Cost of urticaria, 0
- cost_immunotherapy_related_pain
Cost of immunotherapy related pain, 0
- cost_diarrhea
Cost of Diarrhea, 3.2
- cost_hypotension
Cost of hypotention, 0
- cost_vomiting
Cost of Vomiting, 8.45
- cost_infection
Cost of Infection, 222.33
- cost_hypersensitivity_reaction
Cost of Hypersensitivity reaction, 4.13
- cost_capillary_leak
Cost of Capillary leak, 306.37
- cost_pain
Cost of pain, 6.36.
- cost_laboratory
Cost of laboratory services, 141.45.
- cost_hospitalisation
Cost of hospitalisation, 3763.62.
- Temo_unit_mg
Unit dose of Temozolomide (Temo) in milligrams, 50.
- Temo_dose_days
Number of days on Temozolomide per cycle, 5.
- Temo_unit_price
Unit price of Temozolomide, 15.34.
- Iri_unit_mg
Unit dose of Irinotecan (Iri) in milligrams, 40.
- Iri_dose_days
Number of days on Irinotecan per cycle, 5.
- Iri_unit_price
Unit price of Irinotecan, 4.4.
- u_EFS
Utility value for Event-Free Survival (EFS), 0.84.
- u_PPS
Utility value for Post-Progression Survival (PPS), 0.56.
- df_life_table
dataframe representing the Life Table for Jordan:
- age
Numeric vector representing the age groups from 0 to 100.
- prob
Numeric vector representing the mortality rates.